Synthesis and immunoadjuvant activity of 2,2′- O-[2,2′-diacetamido-2,3,2′,3′-tetradeoxy-6,6′-di- O-(2-tetradecyl-hexadecanoyl)-α, α′-trahalose-3,3′-diyl]bis( N- d-lactoyl- l-alanyl- d-isoglutamine)

Abstract

The disaccharide of 6- O-(2-tetradecylhexadecanoyl)muramoyl dipeptide coupled through an α-(1↔1)-α linkage, named in the title, and an analog bearing a single peptide moiety, have been synthesized from 2,2′-diazido-2,2′-dideoxy-α,α′-trehalose. The immunoadjuvant activities of the products were examined.