Abstract
A variety of N-(acyOmuramoyl-dipeptides were synthesized and their immunoadjuvant activities were examined on the induction of delayed-type hypersensitivity to N-acetyl-l-tyrosine-3- azobenzene-4′-arsonate in guinea pigs. It was found that introduction of acyl groups to the 2-amino group in muramoyl-l-valyl- or -l-seryl-d-isoglutamine reduced the activity with the increasing length of the acyl group, although all N-(acyl)muramoyl-l-alanyl-d-isoglutamines were active as an adjuvant. The results suggest that development of the adjuvant activity of N-(acyl)muramoyl- dipeptides is closely related to both the length of the acyl group and the bulkiness of the peptide moiety.
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