Abstract
This research included preparation of Heterogeneous Cyclic compounds (quadrilateral and pentalateral) based on the acidic form of Ciprofloxacin (1) as a starting material. The ester compound (2) was prepared by reacting (1) with ethanol in the presence of sulphuric acid, followed by the reaction with hydrazine-hydrite to obtain the hydrazide compound (3), which was treated with aromatic aldehydes in the presence of absolute ethanol as a solvent to give the Schiff bases (4-6). The quadrilateral cyclo derivatives of B-Lactam (7, 9, 11) were prepared by reacting the Schiff bases with chloroacetyl chloride, using 1,4-dioxan as a solvent and trimethyl amine as a base. The pentalateral oxazolidine cyclo compounds (8, 10, 12) were prepared by reacting the Schiff bases with glycolic acid in the presence of 1,4-dioxan as a solvent. All prepared compounds were characterized using IR spectroscopy and melting points to prove the accuracy of the chemical structures
Highlights
which was treated with aromatic aldehydes in the presence
melting points to prove the accuracy of the chemical structures
(365 - 382 )ISSN: 1992 - 0849 (Print), 2616 - 6801 (Online تشخيص مركبات ( : )12,11,8شخصت المركبات بطيف الأشعة تحت الحم ارء ،اظير الطيف اختفاء حزم عند التردد ( ) 1604 – 1591سم 1-ترجع الى مط أصرة ( ) N=CHوظيور حزمة ( )C=Oلحمقة البيريدين عند التردد ( ) 1720 -1718سم 1-وحزمة أخرى عند التردد ( ) 1731 -1727سم 1-ترجع الى مجموعة ()C=O لحمقة اللاكتون ،وحزمة أخرى عند التردد ( ) 2977 – 2972سم 1-تمثل الاىت از ازت المتناظرة والغير متناظرة ترجع الى تردد مجموعة ( )-CH 2داخل حمقة الاوكسازولدين وحزمة أخرى عند التردد ( ) 1274 - 1270سم– 1ترجع الى تردد أصرة ( (C-Fفضلا" عن حزمة التردد ( ) 1058 - 1054سم– 1ترجع الى مط أصرة
Summary
حضرت المركبات من مزج] 0.01مول 3.44 ،غم [ من مركب ( ) 3مع ( 0.01مول ) من الالدييايدات الاروماتية بعد إذابتيما بالايثانول المطمق صعد المزيج لمدة 7ساعات رشح ال ارسب المتكون وجفف ليعطي ناتج بحصيمة كما موضح
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