Abstract
The present report describes the synthesis of heterocyclic compounds on creatinine ring, the synthetic route started from reaction creatinine with chloroacetyl chloride to give compound (1a). Compound (1a) react with urea/thiourea respectively to give compounds (2a-3a),Shiff bases were synthesized by the reaction compounds (2a-3a) with benzaldehyde andm- nitrobenzaldehyde, respectively to give compounds (4a-5a). Esterification of compounds (4a-5a) with α- chloroethylacetate to give compounds (6a-7a). Esters derivatives were synthesized by the reaction compounds (6a-7a) with semithiocarbazide respectivelyto give compounds (8a-9a). The compounds (8a-9a) reacts with NaOH to give compounds (10a-11a). The synthesized compounds characterized by FT-IR and1HNMR spectroscopy. Beside the experimental work, we worked theoretical study involving calculated the energies. Also this study was designed to show the effects of creatinine derivatives on the activities of some transferase enzymes such as: SGOT, and SGPT enzymes in sera.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
