Abstract
Four novel fluorescence sensors bearing a quinolylbenzothiazole platform were synthesized and characterized. The sensors displayed excellent selectivity and highly sensitive fluorescence response to Fe3+ ion in H2O/DMSO buffer solution (1:4 volume ratio; Tris-HCl, 0.01 mol/L; pH = 7.40) at 500 nm originating from quinolylbenzothiazole fluorophore group. Other cations, namely Li+, Na+, K+, Mg2+, Ca2+, Co2+, Ni2+, Cd2+, Cu2+, Zn2+, Mn2+, Ba2+, Pb2+, Hg2+, Al3+, and Eu3+, showed no appreciable change in fluorescence spectrum. The binding stoichiometry between sensors L1, L2, L3, or L4 and Fe3+ was observed to be 1:1 based on fluorescence titration and Jobs plot analysis. The detection limits of L1, L2, L3, and L4 for Fe3+ were found to be 0.155, 0.362, 0.249, and 0.517 μmol/L, respectively. Furthermore, possible utilization of sensors to detect Fe3+ in living HeLa cells was also investigated by confocal fluorescence microscopy.
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