Abstract
Heterocyclic compounds analog have attracted wide attention due to their useful biological properties. Among them, 1,3,4-oxadiazoles have exhibited a wide range of biological properties including anti-bacterial, anti-viral, anti-fungal, anti-cancer, anti-tumor, anti-inflammatory, anti-hypertensive, anti-convulsant and anti-diabetic properties. The purpose of this study was to collect the literature work reported by researchers on oxadiazole derivatives for their various pharmacological activities and also efforts made on this moiety. This study covers the work reported on various biological activities of oxadiazole derivatives.
Highlights
Compounds containing heterocyclic ring systems are of great significance both medicinally and industrially
Many drugs containing oxadiazole are in late clinical trials, including zibotentan (15) as an anticancer agent, ataluren (16) for the treatment of cystic fibrosis and raltegravir (17) an antiretroviral drug for the treatment of HIV infection
All the synthesized compounds of oxadiazole in the present study showed significant activity against the fungi employed at the concentrations of 100μg/ml when compared with that of ketoconazole as standard
Summary
Compounds containing heterocyclic ring systems are of great significance both medicinally and industrially. Oxadiazoles are the heterocyclic compounds comprehend one oxygen and two nitrogen atoms in a five membered ring [1, 2] derived from furan by substitution of two methylene groups (=CH) with two pyridine type nitrogen’s (-N=). They possess a diversity of useful biological effects [3]. Many drugs containing oxadiazole are in late clinical trials, including zibotentan (15) as an anticancer agent, ataluren (16) for the treatment of cystic fibrosis and raltegravir (17) an antiretroviral drug for the treatment of HIV infection. Various 2,5 substituted 1,3,4-oxadiazoles have been shown to be effective against a wide range of gram-positive and gram-negative bacteria [34,35,36]
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