A Brief Review-an Update on 1,3,4-Oxadiazole

Abstract

Abstract: The 1,3,4-oxadiazole nucleus is a biologically necessary scaffold that exhibits a wide range of pharmacological activities. The broad and strong activity of 1,3,4-oxadiazole and their derivatives has established them as significant pharmacological scaffolds, particularly in the treatment of cancer disease. A number of di-, tri-, aromatic, and heterocyclic substituted 1,3,4- oxadiazole derivatives have been reported to possess potent biological activities; these substituted 1,3,4-oxadiazoles had different mechanisms of action and contributed to the development of biologically active drugs. This review is intended to supplement previous reviews by reviewing the literature on the different activities of 1,3,4-oxadiazole derivatives from the last fifteen years. 1,3,4-oxadiazole can be produced in a number of ways and has a wide range of possible pharmacological uses. As a result, scientists have created novel procedures for the production of 1,3,4- oxadiazole derivatives and their use in medicine presently. Anticancer, antibacterial, antiinflammatory, anti-HIV, anti-tubercular, anti-diabetic, antifungal, and other properties are among the activities. In this review, we discussed various research works based on 1,3,4-oxadiazole derivatives synthetic procedure and assessment of different biological activities. Many researchers may find the material on this page helpful, which could lead to the discovery of new medicinal species for society.