Abstract
Purpose: To synthesize and evaluate Schiff base Tin (II) complexes for antioxidant and antimicrobial activitiesMethods: The complexes of Tin (II) chloride with various Schiff base derivative of 2-Hydroxy-1- naphthaldehyde (HN) were synthesized and characterized by various physiochemical techniques, including elemental analysis, ultraviolet–visible (UV-Vis) spectrophotometry, Fourier transform infrared spectroscopy (FTIR), proton nuclear magnetic resonance (1H–NMR), carbon-13 nuclear magnetic resonance (13C-NMR), electron ionization mass spectrometry (EIMS) and conductance studies. Agarwell diffusion and agar-well dilution techniques were used for antimicrobial assessment. Evaluation of the antioxidant activity of the ligands and complexes was accomplished by DPPH radical scavenging assay.Results: The results indicate coordination of deprotonated phenolic oxygen and nitrogen of azomethine with Tin (II) chloride led to the formation of stable complexes. The Tin (II) complexes showed good antimicrobial and antioxidant activities. Compounds (HNPA and [Sn(HNPA)Cl2(H2O)2) were noteworthy (p < 0.05) in this regard with antibacterial activity against Staphylococcus aureus, while [Sn(HNCA)Cl2(H2O)2 and [Sn(HNPT)Cl2(H2O)2 were active against Klebsiella pneumoniae..Conclusion: All synthesized Schiff bases and their Tin (II) complexes showed high antimicrobial and antioxidant activities than their corresponding ligands.Keywords: Schiff base, Ligand, Tin (II) complexes, Antimicrobial, Antioxidant, Deprotonated phenolic oxygen
Highlights
Various metal complexes with bi- and tridentate Schiff bases containing nitrogen and oxygen donor atoms play important role in biological system [1]
Naphthaldehyde and its Sn (II) complexes. These complexes derived from 2-Hydroxyl-1naphthaldehyde were studied in detail for their applications in diverse areas such as antimicrobial and antioxidant activities
In ligand HNPA and its complex [Sn(HNPA)Cl2(H2O)2], the υ C=N bands of free ligand at 1600 cm-1 are shifted to higher wave numbers (1618,1653 cm-1) in the spectra of the complex, indicating coordination of ligand to the tin ion via the azomethine nitrogen atom
Summary
Various metal complexes with bi- and tridentate Schiff bases containing nitrogen and oxygen donor atoms play important role in biological system [1]. 2-Hydroxy-1naphthaldehyde Schiff base complexes are widely studied for its antimicrobial, catalytic and redox properties [7]. These results have led us to derive Schiff bases of 2-Hydroxyl-1-. Equimolar ethanolic solution of 2-Hydroxy-1naphthaldehyde (HN) 0.01 mole (1.7218 g) with 0.01 mole (1.0814g) of o-phenylenediamine (PA) were refluxed with constant stirring for 40 min. Equimolar ethanolic solution of 2-Hydroxy-1naphthaldehyde (HN) 0.01 mole (1.7218 g) with 0.01 mole (1.2758g) of 4-Chloroaniline (CA) were refluxed with constant stirring for 40 min. Equimolar ethanolic solution of 2-Hydroxy-1naphthaldehyde (HN) 0.01 mole (1.7218 g) with 0.01 mole (1.079g) of p- Toludine (PT) were refluxed with constant stirring for 40 min. Equimolar 0.0025mole ethanolic solution of ligands (HNPA, HNCA, HNPT, and HNOT) and 0.0025mole SnCl2.2H2O were refluxed with constant stirring for 2 h.
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