Synthesis and Evaluation of Analgesic and Antioxidant Activity of 3-Phenyl Coumarin Derivatives

Abstract

A series of 3- phenyl substituted coumarin derivatives prepared by reacting substituted aromatic aldehyde with phenylacetic acid. The chemical composition of substituted coumarin derivatives was confirmed by FT-IR, 1H NMR spectra and elemental analysis. Designed 3-phenyl coumarin derivatives were docked with Cyclooxygenase-2 (COX-2) enzyme (PDB CODE: 3Q7D). Compounds were synthesized and evaluated for in-vivo analgesic and in-vitro antioxidant activities depending upon the highest binding affinity. Compounds 02, 10, and 11 exhibited significant analgesic activity. Compounds 09, 04, 01, and 03 showed significant antioxidant potential in the DPPH method, and Compounds 05 and 07 have shown excellent scavenging potential in the nitric oxide scavenging method compared to ascorbic acid. This research work includes the synthesis of 3-phenyl coumarin scaffolds and the evaluation of their analgesic & antioxidant activity.