Abstract
A variety of triterpenoid propargyl amides, prepared from the corresponding acids, was used as substrates for the construction of novel triazole-tethered triterpenoid–AZT conjugates via a click chemistry-mediated coupling with azidothymidine (AZT). Thus, nineteen new hybrids were successfully prepared and evaluated as cytotoxic agents, revealing an interesting anticancer activity of four triterpenoid–AZT hybrids on KB and Hep-G2 tumor cell lines.
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