Abstract
AbstractPoly(α‐malic acid) is of interest for the application as a biodegradable and bioadsorbable drug carrier, which has pendent reactive carboxylic acid groups. In order to provide a biodegradable macromolecular prodrug of doxorubicin (adriamycin, ADR), reducing the side‐effects of ADR and exhibiting effective antitumor activity, ADR residues were covalently attched to poly(α‐malic acid) via ester or amide bonds to give poly(α‐malic acid)/ester/ADR conjugate 1 or poly(α‐malic acid)/amide/ADR conjugate 2, respectively. The release rate of ADR from the poly(α‐malic acid)/ester/ADR conjugate 1 was faster than that from the poly(α‐malic acid)/amide/ADR conjugate 2 in buffer solution (pH 7,4) at 37°C. While the cytotoxic activity of poly(α‐malic acid)/ester/ADR conjugate 1 is as strong as that of free ADR against p388D1 lymphocytic leukemia cells in vitro, the cytotoxic activity of poly(α‐malic acid)/amide/ADR conjugate 2 is much lower.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
