Abstract
To develop new anti-inflammatory and DNA cleavage agent with improved pharmaceutical profile, five quilinium salt based compounds have been synthesized and x-ray characterization of these quinolinium salts have been reported here. These quinolinium salts have potential to show the better anti-inflammatory activity as well as DNA cleavage activity. The anti-inflammatory activities of quinolinium salts 1–5 have been evaluated by complete Freund's adjuvant (CFA) induced rat paw edema method. The DNA cleavage activities of quinolinium salts 1–5 were analyzed by using plasmid pBR322. The crystal structure of quinolium salt 1, 2 and 3 have shown the intermolecular non-covalent interactions such as cation···π, π···π, CH···π, CH···X (X = I and Br) and CH⋯N interactions.
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