Synthesis and Characterization of the First Pair of an Unlocked and a Locked Self-inclusion Complex from a Permethylated α-Cyclodextrin Derivative

Abstract

Abstract To examine self-inclusion phenomena, we intentionally synthesized the first pair of an unlocked and a locked self-inclusion complex, 3h and 4h, from a permethylated α-cyclodextrin-azobenzene dyad through an m-xylylene spacer. A d2-labeled complex 4d was also prepared for decisive 1H NMR spectral assignments. In both complexes, the guests were bound in the CD cavities in a similar manner, whereas the mutual orientation of the spacer and the nearest benzene ring was unexpectedly different.