Synthesis and Characterization of Stable Iron Oxide Nanoparticle with Amino Covalent Binding on the Surface for Biomedical Application

Abstract

The success for biomedical application of nonmaterial always depends upon its colloidal stability. Thus, in the current study we report a suitable method for preparation and functionalization of Iron oxide nanoparticles with amino group at its terminal end. The optimization of magnetite was studied to enhance physico-chemical and magnetic properties. Thus, the particles were first coated with amino groups and then subjected for surface functionalization using polyethylene glycol. The surface topography and average size distribution of the nanoparticles was determined by performing characterization using Transmission electron microscopy, dynamic light scattering and diffraction pattern. The zeta potential and hydrodynamic size was studied as function of pH. An adequate surface modification involving covalent approach based on surface chemistry of salts provides PEG modified iron oxide nanoparticles as suitable for biomedical application as it may increase circulation of the particles in blood as new monolayer is capable of conjugating and allowing targeted uptake of biomolecules into tumors.