An original route to target delivery via core-shell modification of SPIONs

Abstract

A adaptable method for grafting of amino group with polyethylene glycol (PEG) onto the surface of Superparamagnetic iron oxide nanoparticles (SPIONs) has been build up in order to develop magnetic core shell with enhanced properties (magnetic, colloidal stability, physico-chemical). In a straightforward and reproducible method new core shell SPIONs were developed based on diazonium salt chemistry highly and their application highly depends on monodispersity, size, and aqueous stability. The hydrodynamic size and zeta potential was studied as function of ionic strength. The surface morphology and average size distribution of magnetite nanoparticles was determined using transmission electron microscopy and diffraction pattern. The saturation magnetization was also achieved. With flexible surface chemistry, these surface modified SPIONs with amino groups could facilitate their use in biomedicine application by conjugating biomolecules improving the cellular targeting.