Abstract
This work includes preparing of some new derivatives of pyrimidine ,
 pyrazole , and isoxazole from the reaction between
 
 benzylideneacetophenone (chalcone) (1) and hydrazine derivatives in the
 presence of sodium acetate and dry acetone to obtain heterocyclic
 compounds (2-6).
 
 Reaction of (2) with different substituted benzaldehydes in absolute
 ethanol and drops of glacial acetic acid gave Schiff bases derivatives (8-
 10) respectively. Schiff bases (8-10) were reacted with sodium azide in
 THF to give tetrazole derivatives (11-13). Reaction of (2) with sodium
 nitrate and concentrated hydrochloric acid , then with phenol gave diazo
 compound (7).
 
 The prepared compounds were diagnosed mediated FT.IR,'H-
 NMR,UV/Vis spectra, melting points were recorded and the purity was
 checked through TLC technique. The biological effectiveness were
 measured for some prepared compounds.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
