Synthesis and Characterization of Some Chlorosubstituted Azoles and their Screening Against Some Mushroom Crop Pathogens and Study of their Efficacy on Growth of Oyster Mushroom spp.

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Applicability of azoles possessing nitrogen and oxygen atom as a heteroatom are well known in the fields of agriculture, medicine, and industries. One of the fast-growing research areas in the heterocyclic chemistry has been directed towards the synthesis of isoxazoline derivatives; as a structural unit frequently found in natural products and many bioactive molecules. They exhibit various biological activities. Isoxazoline having Imidazole moiety have been reported as an ingredient of various pesticides useful for the control of pest in agriculture arena. Some derivatives exhibit antimicrobial and growth regulatory properties. The farmers in the tropical belt of Vidarbha region of Maharashtra were in the habit of cultivation of mushroom. However, these mushroom growers are worried about susceptibility of their crop towards some plant pathogenic attack. As a result, the amount of yield they have produced has been found incommensurate with their efforts and investment. The greater efficacy of biological properties exhibited by isoxazoline moiety stimulated the research work to develop new synthetic approaches for their synthesis and study their activity. To safeguard the mushroom crop from the pathogenic attack, there arose a need to develop a potent pathogen inhibiter. Thus, with this aim, we attempted to synthesis some nitrogen and oxygen containing chlorosubstituted isoxazolines and studied their efficacy against some mushroom crop affecting pathogens viz. some fungi V. fungicola, G. roseum and some bacteria viz. B. gladioli, P. fluorescene, P. alcaligens, P. stutzeri. Beside this, efficacy of synthesised compounds on development of Pleurotus sajor-caju have been studied.