Abstract
In this study, new salicylaldehyde derivatives containing a 1,2,3-triazole group (5a-c) and their Schiff bases (6a-c) were synthesized and their structures were characterized by FT-IR, 1H(13C) NMR and elemental analysis spectroscopic methods. The crystal structure of the triazole compound 5c was investigated by X-ray diffraction study. Then, UV-Vis absorption properties were studied and the effects of different solvents on absorption were investigated. In the UV-vis spectra, π-π* and n-π* transitions were observed in the range of 280-480 nm. Especially, the absorption band at 400-480 nm range for 6a-c in MeOH gave the idea that they were caused by tautomeric conversion from phenol-imine to keto-amine in their structure. Acetylcholinesterase Inhibitory activity studies are very important for research on the treatment of Alzheimer's disease, so the synthesized compounds were screaned for their AChE inhibitory activities. According to the results obtained, both 1,2,3-triazole compounds and Schiff bases showed comperable inhibitory activity. In particular, the activity of compound 6b (IC50: 12.85 ± 0.026 µM) was determined to be approximately considerably higher than the standard Galantamine (IC50: 139.4 µM).
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