Synthesis and Characterization of Schiff Base of 2-Acetyl-5-Methylfuran Glyoxime Hydrazine and its Metal (II) Complexes and Their Evalution for Antibacterial and Antifungal Activities

Abstract

Two hydrazone Schiff base was synthesized by the interaction of ethanolic solution of antiglyoxime hydrazine with 2-acetyl-5-methylfuran to obtain the Schiff base. The complexes of Mn(II), Fe(II), Ni(II) and Cu(II) and their Schiff base were synthesized and characterized based on solubility, percentage yield, elemental analysis, melting point and decomposition temperature, infra-red spectra (FT-IR), conductivity measurement, magnetic susceptibility and water of crystallisation. The ligand and the complexes were coloured and stable at room temperature. They were soluble in acetone, DMSO, ethanol, methanol, hexane, chloroform, carbontetrachloride, benzene and DMF but insoluble in distilled water. The melting point temperature of the ligand was 118oC while the decomposition temperatures for the complexes were found to be between 295-312oC. The molar magnetic susceptibility of the complexes were in the range of 3.55 x 10-3 – 1.42 x 10-2erg.G-2mol-1. Molar conductance values of 2.17 – 2.87Ω-1cm2mol-1 show non electrolytic nature of the complexes. The spectral data of the ligand showed bands in the range 1581–1607cm-1 revealing the formation of the azomethine group. A band between 760-795cm-1 indicates the metal nitrogen bonds. The elemental analysis of the complexes showed the metal ligand ratio of 1:2 (M:2L). The antibacterial and antifungal studies showed that the complexes exhibited higher antibacterial and antifungal activities than the ligand but lower than the reference drugs.