Abstract
The photo-responsive ABA amphiphilic triblock copolymers polylactide-block-poly(ethylene glycol)-block-polylactide with o-nitrobenzyl esters as the photocleavable block-linker (defined as PLA-NB-PEG-NB-PLA), were prepared by controlled ring-opening polymerization (ROP) of D, L-lactide (D, L-LA) using two o-nitrobenzyl groups terminated polyethylene glycol as initiator. Flower-like micelles formed after these copolymers were dissolved in aqueous solution. Introduction of shortened PEG and PLA chains, although resulting in the reduction of micelle sizes, would bring about higher photolysis rate and loading efficiency of DOX. The flower-like micelles showed excellent photocleavage properties, thereby, burst release of DOX could be induced after UV irradiation, which will have potential application in biomedical materials.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.