Synthesis and Characterization of Palladium Catalyzed (Carbon-carbon Bond Formation) compounds

Abstract

In atmospheric condition, cesium carbonate was dissolved in water in a small bottle. Aryl halides, phenyl boronic acid, tetra butyl ammonium bromide, Bis (tri phenyl phosphine) palladium II chloride catalyst and toluene were taken in another small bottle. The contents of both the small bottles were added in a pressure tube. Heating of reaction mixture was done at 80-900C and then stirred until the reaction completion, which was confirmed by TLC. After this, the reaction mixture was extracted with ethyl acetate and the organic layer was washed with brine solution and then filtered by buckner funnel prepared with celite bed. Sodium sulphate was added to the filtrate, filtered again using cotton bed and silica (60-120 mesh size) was added to the filtrate and evaporated by using rotavapour. Through column chromatography, the crude product obtained was purified using Ethyl acetate/Hexane as mobile phase.Bis (tri phenyl phosphine) palladium II chloride catalyzes the reaction of aryl halides and phenyl boronic acid at 80-900C giving moderate to high yields even when the catalyst quantity used was low.