Synthesis and Characterization of Novel OAT‐g‐PMMA Matrices: Its Application in Controlled and Colonic Drug Delivery

Abstract

AbstractThis research reports synthesis of novel graft copolymers of oatmeal (OAT‐g‐PMMA) using a methyl methacrylate monomer via the “microwave‐assisted” technique which were applied as matrices. The synthesized matrices were used to develop the bioavailability of model drug (5‐amino salicylic acid (5‐ASA)) for colon‐targeted delivery. Characterization of novel synthesized matrices includes intrinsic viscosity, 13C‐CP/MAS solid‐state NMR spectroscopy, FTIR, DSC, SEM, TGA, UV, and elemental analysis. In vitro release studies of 5‐ASA were performed in simulated gastric medium (pH 2) and simulated intestinal medium (pH 7 and 7.4). The release rate of 5‐ASA from OAT‐g‐PMMA matrices was found to be slower than oatmeal in simulated gastric media. However, the reverse trend was observed in simulated intestinal medium. These results suggest that synthesized novel OAT‐g‐PMMA matrices are more suitable for oral delivery of applied model drug as compared to starting biopolymer (oatmeal) with special reference followed by the Fickian diffusion mechanism as a colonic drug carrier.