Abstract
Abstract 1-Indanone and its derivatives are well known for their diverse biological activities, making them valuable scaffolds in drug design and medicinal chemistry. Among the various synthetic methodologies available for modifying such structures, the Suzuki-Miyaura cross-coupling reaction is a prominent approach for constructing carbon-carbon bonds. In this study, the palladium-catalyzed Suzuki-Miyaura cross-coupling reaction of 5-bromo-1-indanone with four different boronic acids—phenylboronic acid, 4-methoxyphenylboronic acid, 4-thiomethylphenylboronic acid, and 4-ethylphenylboronic acid—was investigated. The reactions yielded the corresponding 5-substituted indanone derivatives, which were characterized by 1H and 13C NMR spectroscopy to confirm their structures and assess their purity. This study demonstrates the efficiency and versatility of the Suzuki-Miyaura reaction in functionalizing 1-indanone derivatives, providing a robust route for synthesizing structurally diverse compounds with potential applications in medicinal chemistry. The newly synthesized and characterized 5-indanone derivatives have potential applications in the development of new drug candidates. These compounds may contribute to advancements in treatments for various diseases, including cancer and Alzheimer’s disease, by integrating into biologically active structures.
Published Version
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