Synthesis And Characterization Of New 1,2,4- Triazine Based On 2,5-Dihydrazino-1,3,4- Thiadiazole

Abstract

The chemistry of 1,2,4-triazine derivatives received a great deals of attention in recent year due to the use of such ring system as the core structure in many heterocyclic compound covering wide range of applications in many different field especially in industrial and biological fields. An efficient aza Diels-Alder reaction have been used in this presentation to prepare the hetero adducts represented by N2,N5-di(3,5,6-tri aryl-5,6-dihydro-1,2,4-triazine-4(3H)-yl)-1,3,4-thiadiazole-2,5-diamino( 9-20)from hetero dienes and hetero dienophile. However the preparation starting form 1,3,4-thiadiazole-2,5 dithaiole (1) which converted directly to the dihydrazino derivatives(2) which then afford under condensation reaction hetero dienophile represented by 2,5-bis Schiff bases of 1,3,4-thiadiazole(3-6) by its reaction with substituted benzaldehyde . The last compound were reacted through one-pot free solvent aza Diels-Alder reaction with appropriate hetero diene( hydrazine with substituted benzaldehyde in ratio 1:2) (7&8 ) to afford 1,2,5-triazine derivatives (9-20) using grinding and MWI techniques as a types of green chemistry approaches.