Synthesis and characterization of mesoporous SBA-15/propranolol hydrochloride for controlled drug release study

Abstract

Propranolol hydrochloride was incorporated into SBA-15 mesoporous material host by impregnation method to obtain host-guest nanocomposite material (SBA-15)-propranolol hydrochloride. By spectrophotometry, the amount of propranolol hydrochloride assembly was determined to be 382.05 mg/g (drug/SBA-15). Powder X-ray diffraction test results indicated that during the process of incorporation the framework of the molecular sieve was not destroyed and the molecular sieve still remained its structure ordering. Fourier transform infrared spectra showed that the framework of the prepared host-guest material was remained in good condition. Low-temperature nitrogen adsorption-desorption at 77 K results showed that the surface area and the pore volume of (SBA-15)-propranolol hydrochloride host-guest material decreased compared to those of the host molecular sieve, indicating that propranolol hydrochloride guest molecules have partially occupied the channels of the molecular sieve. Transmission electron microscopy and scanning electron microscopy results indicated that two-dimensional hexagonal mesoporous pore channels of the molecular sieve were retained and (SBA-15)-propranolol hydrochloride composite material remained fibrous crystals and the average diameter of sample was 336 nm. It was discovered in drug release principle in the simulated body fluid that the effective release time of the drug reached 30 h and the maximum cumulative released amount of propranolol hydrochloride was 99.3 %. When drug release time arrived at 5 h in the simulated gastric juice, the maximum cumulative released amount was 51.2 %.When drug release time arrived at 9 h in the simulated intestinal fluid, the maximum cumulative released amount was 70.1 %. The drug sustained release results showed that SBA-15 is a well-controlled drug release carrier.