Loading of Propranolol Hydrochloride on MCF and Sustained Release

Abstract

Aims: Adsorption conditions of propranolol hydrochloride onto MCF are optimized. Properties of this adsorption system are studied. The sustained release properties of propranolol hydrochloride in the loading system are also researched. Background: In today's society, demand for drugs is getting higher and higher. With the development of nanotechnology, it is easier to immobilize drugs on nanomaterials, which can easily transport drugs in the human body. It can control drug release, reduce side effects, improve drug efficacy, and develop drug orientation. Objective: The purpose of this study was to load propranolol hydrochloride, a drug for the treatment of heart disease and hypertension on the MCF nano-mesoporous material to prepare a sustainedrelease preparation and investigate the release law of propranolol hydrochloride in simulated human body fluid. Methods: Nanometer mesoporous MCF (mesocellular foams) silica material was prepared in acidic medium using triblock copolymer poly(ethylene glycol)-block-poly(propyl glycol)-block-poly(ethylene glycol) as template and tetraethoxysilane as silica source. Propranolol hydrochloride drug was incorporated into the MCF mesoporous material by the impregnation method to prepare MCF-propranol hydrochloride host-guest composite material. The loading amount of drug was calculated by spectrophotometry and difference subtraction method. Results: The loading amount of drug calculated by spectrophotometry and difference subtraction method was 385.5 mg·g-1 (propranolol hydrochloride/MCF). The adsorption process of propranolol hydrochloride in MCF belongs to the quasi-second-order kinetic process. Adsorption process ΔH0 = -19.11 kJ·mol-1, is an exothermic process, ΔG0 < 0, the adsorption process is a spontaneous process. The effective release time of drug lasted up to 32 h and the maximum cumulative released amount was 99.4 % through the experiment of drug sustained release in the simulated body fluid. In the simulated gastric juice, the release time of drug reached 6 h, and the maximum cumulative released amount was 56.6 %. When drug release time arrived at 10 h in the simulated intestinal fluid, the maximum cumulative released amount was 71.3 %. Conclusions: The influence of the release rate of propranolol hydrochloride molecules from MCF mesopores was demonstrated, since it results in a very slow drug delivery from the nanocomposite system. Thus, it is concluded that the prepared MCF is an efficient drug sustained-released carrier.