Abstract
Inulin is a particularly effective drug delivery vehicle as compared to other biodegradable polysaccharides because of its unique and flexible structure, protective and stabilizing properties, and organ targeting abilities. This strategy may result in targeted, delayed, and regulated release of medications and biomolecules as well as increased bioavailability and improved cellular absorption. In the present study, thermogravimetric analysis (TGA), Fourier transform infrared spectroscopy (FTIR), 1H-NMR, and ultraviolet spectroscopy were among the techniques used to further characterize the physicochemical properties of inuline. The inulin-g-[N-sulfamethoxazole maleic amic acid] (INMS) was prepared and used. INMS efficacy against bacterial activity was also examined. In order to examine the activity of INMS in vivo, mice were underwent to second-degree burn. The results showed, after three days, the basic media produced better regulated drug release than the acidic one. This was discovered by contrasting the pace at which the amide drug polymer hydrolyzed in each media. It was discovered that a drug polymer with altered drug release and a prolonged duration of action has as an adhesive probity. The present results found that INMS has a significant antibacterial effect on burned wound isolated bacteria. The in vivo performance using a natural polymer as a drug carrier results a great healing of skin wound of mice. Thus, the present study is aimed to modify the inulin to serve as a scaffold for various drug delivery systems.
Published Version
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