Abstract
Nowadays the use of magnetic nanoparticles (MNP) in medical applications has exceeded expectations. In molecular imaging, MNP based on iron oxide coated with appropriated materials have several applications in vitro and in vivo studies. For applications in nanobiotechnology these MNP must present some characteristics such as size smaller than 100 nanometers, high magnetization values, among others. Therefore the MNP have physical and chemical properties that are specific to certain studies which must be characterized for quality control of the nanostructured material. This study presents the synthesis and characterization of MNP of magnetite (Fe3O4) dispersible in water with perspectives in a wide range of biomedical applications. The characterization of the colloidal suspension based on MNP stated that the average diameter is (12.6±0.2) nm determined by Transmission Electron Microscopy where the MNP have the crystalline phase of magnetite (Fe3O4) that was identified by Diffraction X-ray and confirmed by Mossbauer Spectroscopy. The blocking temperature of (89±1) K, Fe3O4 MNP property, was determined from magnetic measurements based on the Zero Field Cooled and Field Cooled methods. The hysteresis loops were measured at different temperatures below and above blocking temperature. The magnetometry determined that the MNP showed superparamagnetic behavior confirmed by ferromagnetic resonance.
Highlights
The synthesis of magnetic nanoparticles (MNP) has received great interest in recent years because of new physical and chemical properties of materials at nanoscale
This paper presents a synthesis route to prepar MNP as well as the morphological, structural and magnetic characterization of the material synthesized to control quality of these MNP that are presented as promising particles in biomedical applications
In order to access the structural parameters, the Κα1-Κα2 doublet separation (Rachinger correction) and background corrections were performed by using a pseudoVoigt function (PVF), in a interactive method of profile fitting by least squares method[19,20]
Summary
The synthesis of magnetic nanoparticles (MNP) has received great interest in recent years because of new physical and chemical properties of materials at nanoscale. Iron oxide MNP with crystalline phase corresponding to magnetite appears as an important nanomaterial for various biomedical applications such as: (i) cellular therapy as cell labeling, targeting, and as a tool for cell-biology research to separate and purify cell populations, (ii) tissue repair; (iii) drug delivery, (iv) magnetic resonance imaging (MRI), (v) hyperthermia, (vi) magnetofection, among other[7,8,9]. In clinical applications, it is desirable MNP with sizes between 10 and 200 nm, because MNP larger than 200 nm can be filtered by the human spleen, and MNP smaller than 10 nm can be removed by renal clearance[10].
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