Abstract
The present study reports synthesis and characterization of sodium alginate (Na-ALG) based composite hydrogels using polyaniline (PANI), poly(o-phenylenediamine) (POPD), poly(1-naphthylamine) (PNA), and poly (vinylidene fluoride) (PVDF). The synthesised hydrogels were investigated for their spectral, morphological and rheological properties. Metformin hydrochloride (MFH) was chosen as a model drug to study the release profiles using intestinal fluid pH of 7.4. Approximately 99 % drug release was attained for POPD/Na-ALG at 37 °C over a period of 12 h. Release kinetics was confirmed by employing the zero-order, first-order, Higuchi and Korsmeyer-Peppas models. It was found that almost all composite hydrogels followed the zero order and Korsmeyer-Peppas models. The incorporation of conducting polymers as crosslinking agents was found to have a significant impact on the release behaviour and this property could be utilised to optimise and control the release of metformin hydrochloride as per desirable dosages.
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