Synthesis and characterization of biodegradable gum ghatti-cl-poly(AA-co-NIPAm)/GO based hydrogel for metformin and sodium diclofenac combined drug delivery system

Abstract

In the current study, we investigated whether combining metformin with diclofenac, a non-steroidal anti-inflammatory medicine (NSAID), would be effective in examining the complex formation and analyzing the types and intensities of complexes that may occur from interactions between metformin and diclofenac. At varied pH levels and at body temperature, the interaction of metformin with diclofenac was examined in-vitro. FTIR spectra, FE-SEM analysis, DSC analysis, DLS analysis, and drug loading studies were used to characterize the structure, morphology, thermal analysis, and average size values of the generated hydrogel. Hydrogel was loaded with metformin hydrochloride and sodium diclofenac (DS) as a model drug, and the drugs were released in a pH-dependent manner. The zero-order, and first-order kinetic models, the Korsemeyar-Peppas model, the Higuchi model, and the Hixson-Crowell model have all been used to study the drug release kinetics and mechanism. Studies on drug release showed noteworthy behaviors in relation to physiologically modeled pH’s, with a high release rate at pH = 7.4. However, both metformin and sodium diclofenac medication showed a Fickian mechanism at pH 7.4. Combination therapy may lower the single agent's effective dosage and inhibit metabolic rescue mechanisms. To identify potential adverse effects on people, more research is required.