Abstract
New organic compounds were prepared with two groups of azetidine-2-one, respectively.And that through the first two steps: New compounds were prepared with two groups of azomethine, by reacting benzaldehyde derivatives with primary amino compounds with di-amino groups. The result was diagnosed by following TLC, M.P, FT.IR.The second step: The azomethine compounds prepared in the previous step reacted with acetic acid dichloride with different molar numbers (1:2) and were diagnosed spectroscopically and physically by (TLC, M.P, FT.IR,H1NMR,C13.NMR.C.H.N.X.) to confirm the correctness of the structural formula of the resulting compounds. Finally, the effect of these prepared compounds on types of gram-positive and gram-negative bacteria (Escherichia Coli, Klebsiella pneumoniae, Staphylococcus aureus P.aeruginosa.) was studied and the results were compared with types of drugs available in pharmacies (Cefotaxime (C.C.X 10) 5 mg/ disc, Chloramphenicol (C.C.30) 30mg/ disc, Cefixime (C.F.M5) 10mg/ disc, Amoxicillin (A.M.C30) 30 mg/ disc). The results were very satisfactory against the growth of types of bacteria, and the reason was due to the increase in the number of azetidine-2-one rings, meaning the greater the number of these rings, the greater the killing of bacteria.
Published Version
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