Abstract
The bioactive glass (BG) system of SiO2-P2O5CaO-SrO-Ag2O-ZnO was synthesized by the sol-gel route. Transmission electron microscopy (TEM) analysis showed that the mean particle size of as-synthesized nanoglass was ~50 nm. The effect of zinc and silver content on cell viability, antibacterial properties, and the formation of hydroxyapatite (HA) on the BGs were investigated. The synthesized compounds were soaked in simulated body fluid (SBF) for 21 days to study the bioactivity of the new glass composition. Results demonstrated that samples BG and BG-A2Z3 showed higher bioactivities in comparison with other specimens. The formation of HA was observed on the first day of soaking. In order to investigate the biocompatibility and antibacterial properties of the samples, MTT assay and antibacterial tests against E. coli were performed. The BG-A2Z3 sample showed the optimal properties of antibacterial, biocompatibility, and bioactivity that is the best candidate for orthopedic applications.
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