Synthesis and characterisation of polymer containing dye‐affinity ligand grafted to magnetic nanoparticles for enteric insulin delivery

Abstract

In the present work, a novel technique is reported for the surface grafting of polymer containing famous dye-affinity, Procion blue MX-R, onto modified iron oxide nanoparticles with 3-mercaptopropyltrimethoxysilane. The grafted nanocarrier was synthesised by free radical polymerisation followed by coupling with Procion blue and then characterised by Fourier transform infrared spectroscopy, thermogravimetric analysis, elemental analysis and also transmission electron microscopy. The grafted magnetic nanocarrier was used for enteric insulin delivery. The profile of the insulin uptake by synthesised nanocarrier indicated excellent accessibility of the polymer contains Procion blue. Scatchard analysis reflected that the capacity of the polymer containing dye-affinity ligand nanocarrier was about 12 µmol g−1 at pH 5. The balance sorption information of insulin by polymer contains Procion blue nanocarrier which were verified by Freundlich, Temkin, Langmuir and Redlich–Peterson models. The magnetic nanocarrier showed maximum of 95% drug release in acidic medium of pH 1.2, and about 80% drug release was recorded in intestine medium of pH 7.4.