Synthesis and Biological Study of 2-( 5-aryl-4,5-dihydro-1-substituted-pyrazol-3-yl )-Substituted-Naphthalene-1-Ol

Abstract

The literature survey reveals that pyrazoline derivatives have been studied extensively because of their ready accessibility, diverse chemical reactivity, broad spectrum of biological activity and variety of Industrial applications. Pyrazolines with sulphonamidoaryl substituent at 3-position show cerebroprotective, antidepressant activity , anti-implantation activity, hypoglycemic activity. Due to this vital biological roll of pyrazoline derivatives it was thought to synthesized titled pyrazolines. 2-Acetyl-1-naphthol is prepared by Modified Nenchi’s method which on treatment with furfuraldehyde and KOH gives 1-(1-hydroxy naphthalen-2-yl)-3-(furan-2-yl) prop-2-ene-1-ones in excellent yield. The chalcone when subjected to hydrazine / phenyl hydrazine/ semicarbazide / 2,4 dinitro phenyl hydrazine / isonicotinic acid hydrazide in DMF solvent to gives 3-(1-hydroxy naphthalene-2-yl)-5-(furan-2-yl)-1-substituted pyrazolines in 35-45% yield. All the melting points were taken in silicon oil bath with open capillary tubes and are uncorrected. 1 H NMR spectra were recorded on a Brucker AC300 FNMR spectrometer (300MHz), using TMS as an internal standard. IR spectra were recorded on a Nicolet-Impact 400 FT-IR spectrometer. Thin Layer Chromatography on silica gel-G, was used to check the purity of the compounds. Microanalysis of nitrogen was obtained on Colman 29-N analyzer. The synthesized compounds were characterized by elemental analysis, 1H NMR, IR Spectroscopy. All Newly synthesized compound were scanned for their antimicrobial and antifungal activity and all newly synthesized compounds shows an excellent antimicrobial and antifungal activities.