Synthesis and biological screening of novel series of 2-(4-hydroxy-3-methoxy-5-nitro-phenyl)-[1,3,4]oxadiazole by conventional and non conventional techniques

Abstract

Novel acid hydrazide 1 when reacted with a series of different carboxylic acids in presence of phosphorous oxychloride to give novel series of 2-(4-hydroxy-3-methoxy-5-nitro-phenyl)-[1,3,4]oxadiazole 3a-3f. Use of conventional and non-conventional techniques is adapted to study the duration time of reaction. These oxadiazole compounds are studied by using spectral analysis like 1H NMR, FT-IR and mass spectroscopy. Further they are screened for antibacterial and anti-fungal biological activities.