Chem.Dept./ College of Education Ibn-Al-Haithem University of Baghdad.

Abstract

This work includes synthesis a series of some new derivatives of triazine from reaction between the sulfur amino acid (L-cysteine) and different aldehydes in dry ethanol to obtain thiazolidine ring as diastereo isomers (Cis and Trans)- 2- alkylthiazolidine-4- carboxylic acids (1).
 The thiazolidine derivatives (1) suffered esterfication reaction of carboxylic acid in presence of drops of concentrated sulfuric acid as a catalyst to give the esters :
 ethyl 2- alkylthiazolidine -4 - carboxylates (2), which reacted with hydrazine hydrate in (addition- elimination) reaction to give acid hydrazides : 2-alkylthiazolidine-4-carbohydrazides (3). Acid hydrazides (3) were reacted with acetyl chloride by (NH) acetylation reaction to form: 3- acetyl-2-alkylthiazolidine -4 - carbohydrazides (4). 
 The last step includes cyclization reaction of compound (4) to yeild triazine-1-one derivatives (5), which undergo tautomerization phenomena: triazine -1- ol (6). Triazine derivatives were expected to be biologically active.