Synthesis and Biological Evaluation of Some Succinimide Hybrid Molecules

Abstract

In this study, a new series of succinimide hybrid molecules containing isothiocyanate, coumarin, isatin, and furan moieties was synthesized and screened for α-glucosidase and antioxidant activities. Preliminary results revealed that all molecules showed good α-glucosidase inhibition effectiveness. Antioxidant activities of the hybrid molecules were determined using cupric reducing antioxidant capacity (CUPRAC) and ferric reducing antioxidant power (FRAP) assays. Also, the radical scavenging activities of the synthesized compounds were assayed by using $${\text{ABT}}{{{\text{S}}}^{{\centerdot {\text{ + }}}}}$$ and $${\text{DPP}}{{{\text{H}}}^{\centerdot }}$$ methods. The results showed that all compounds exhibited moderated to high scavenging activity.