Abstract
Objective: Some new imidazole derivatives (3i-xii) were synthesized as per design synthetic protocol scheme. The structures of newly prepared compounds were confirmed by modern analytical technique and elemental analysis. Methods: All the synthetic compounds were screened for their antimicrobial activity against bacterial results showed good to remarkable activity. The MIC (minimum inhibitory concentration) values were determined by comparison to ciprofloxacin (anti-bacterial) and fluconazole (anti-fungal) as standard drug. Among them, compound 3iv and 3x exhibited notable antimicrobial activity. These compounds may be used as new template for the searching of potential antimicrobial agents. Results: The purity of the compound was verified with the help of TLC (B: A, 9:1). % age of yield was found 83% and melting point noted 151-1520C. Compounds (3ii, 3viii and 3ix) were shown moderate activity against E. coli, S. aureus, M. luteus and K. pneumonia, whereas compounds (3iii, 3vii, 3xi and 3xii) showed mild activity against few bacterial strainsμg/ml. The compounds of electron releasing imidazole derivatives (3ii, 3iv, 3viii, 3ix, 3x and xi) presented comparatively better anti-fungal activity than the compounds of electron withdrawing imidazole derivatives (3iii, 3vii and 3xii). Conclusion: The biological activity result revealed that all the newly synthetic compounds 3i-xii [4-(biphenyl-4-yl)-2-(substituted phenyl)-1H-imidazole] exhibited better antibacterial activity as compared to antifungal activity in compare to reference drug. Peer Review History: Received 7 February 2017; Revised 11 March; Accepted 13 March, Available online 15 March 2017 Academic Editor: Dr. Asia Selman Abdullah, Al-Razi university, Department of Pharmacy, Yemen, asia_abdullah65@yahoo.com UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file: Reviewer's Comments: Average Peer review marks at initial stage: 6.5/10 Average Peer review marks at publication stage: 8.5/10 Reviewer(s) detail: Dr. Emmanuel O. Olorunsola, Department of Pharmaceutics & Pharmaceutical Technology, University of Uyo, Nigeria, olorunsolaeo@yahoo.com Dr. Xinwei Li, Jilin University, China, lixinwei100@jlu.edu.cn This article has been cited by: Recent developments in orally disintegrating mini tablets Sachin Sarashetti, Vikas Jain, Gowda D V, Pooja Mallya, Satish Babu. International journal of research in pharmaceutical sciences 2020, 11(3), 3606-3612. Pubmed
Highlights
Nitrogen containing heterocyclic play vital role in pharmaceutical industries.The main aim of medicinal chemist in the recent times has been to develop drugs with enhanced their efficacy and duration of action and by decreasing their toxicities and side effects as well as creating new drugs by molecular modification[1,2]
Imidazole is an important group of compounds reported to have different biological activities and the present study was undertaken in order to synthesize some new derivatives of imidazole and related fused heterocyclic compounds and screen for their antimicrobial activity[6,7,8,9,10,11]
Among the various classes of heterocyclic compounds, imidazole is an important component of pharmacologically active compounds and a part of various available marketed drugs like Azathioprine (Leukemia), Metronidazole (Protozoal and antimicrobial activity, trichomoniasis, amoebiasis and giardiasis), dacarbazine (Hodgkin’s disease), tinidazole, ornidazole, satranidazole (c 10213 go), cimetidtne, carbimazole, tolazoline, naphazoline, tetrahydrozoline[12,13,14]
Summary
Nitrogen containing heterocyclic play vital role in pharmaceutical industries.The main aim of medicinal chemist in the recent times has been to develop drugs with enhanced their efficacy and duration of action and by decreasing their toxicities and side effects as well as creating new drugs by molecular modification[1,2]. In the present studies it has been thought to synthesize newer imidazole derivatives and the structures of the synthesized compounds confirmed on the basis of their elemental analysis and modern analytical techniques such as IR, 1H-NMR and Mass spectral data results. General procedure for synthesis of 4-(Biphenyl-4yl)-2-(substituted phenyl)-1H-imidazole (3i-xii): Biphenyl-2-oxoacetaldehyde (2) was refluxed with different aromatic aldehyde in presence of ammonium acetate and glacial acetic acid.
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
