Abstract
Liquisolid formulations have attracted substantial interest as an efficient means of improving the dissolution and ultimately bioavailability. The technique is based upon the admixture of drug loaded solutions with appropriate carrier, coating materials and use of non-volatile solvent causes improved wettability. The inclusion complexes of drug with beta cyclodextrin (βCD) were formulated by kneading method and highest solubility complex was further used for preparation of liquisolid formulation to get synergistic effect. Also it raises drug incorporation with dissolution enhancement compared with conventional formulation. There are various techniques for bioavailability enhancement, such as altering the pharmacokinetic parameters, inhibition of enzyme etc. For this purpose some herbal inhibitors can be used; ex piperine. The prepared formulations were characterized by FTIR, DSC, PXRD and in vitro dissolution studies. Hence, this liquisolid technique with two way approach of solubility and bioavailability enhancement may found as key aspect in designing of formulations. Peer Review History: Received 1 October 2017; Revised 12 November; Accepted 14 November, Available online 15 November 2017 Academic Editor: Dr. Asia Selman Abdullah, Al-Razi university, Department of Pharmacy, Yemen, asia_abdullah65@yahoo.com UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file: Reviewer's Comments: Average Peer review marks at initial stage: 4.5/10 Average Peer review marks at publication stage: 7.0/10 Reviewer(s) detail: Dr. Leyla Acik, Gazi University, Ankara, Turkey, leylaacik@gmail.com Dr. Emmanuel O. Olorunsola, Department of Pharmaceutics & Pharmaceutical Technology, University of Uyo, Nigeria, olorunsolaeo@yahoo.com Similar Articles: IN VITRO DISSOLUTION STUDY OF GLIMEPIRIDE FROM BINARY AND TERNARY SOLID DISPERSION FORMULATION
Highlights
Liquisolid formulations have attracted substantial interest as an efficient means of improving the dissolution and bioavailability
For powder substrate consisting of a certain carrier and coating powders mixed at various powder excipient ratios (R), there are specific maximum liquid load factors (Lf) which must be employed in order to produce acceptably flowing Liquisolid systems
Liquisolid technique can be optimized for the production of immediate release of drug
Summary
It is generally recognized that poor solubility of drugs is one of the most frequently encountered difficulties in the field of formulation scheme. For a liquid medication incorporated into a given powder substrate consisting of certain carrier and coating materials (e.g. microcrystalline cellulose and silica) blended at a specific excipient ratio (R), there exists an optimum liquid load factor, L0, required to produce acceptably flowing and, simultaneously, acceptably compressible Liquisolid preparations. The minimum possible unit dose weight (Umin) which can be produced by the carrier: coating system may be predicted using equation, having selected the weight W of the liquid medication (per unit dose) and having determined the minimum excipient ratio (Rmin) of the powder system and its corresponding maximum load factor Lmax required to yield a Flowable and compressible Liquisolid system[17]. The formulation were wrapped in aluminum foil, and placed in umber colored bottle[39]
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