Synthesis and biological evaluation of inosine phosphonates

Abstract

The 4′-phosphonomethoxy analogs of inosine and 2′,3′-dideoxyinosine were synthesized and tested for their activity against HCV and HIV, but found to be inactive. During the course of this synthetic investigation, an unexpected oxidative cleavage of the 2′,3′-bond of 2′-deoxyinosine was observed.