Synthesis and biological evaluation of coumarin appended thiazole hybrid heterocycles: Antibacterial and antifungal study

Abstract

In the present investigation, a series of 3-(1-(2-(thiazol-2-yl)hydrazineylidene)ethyl)-2H-chromen-2-one derivatives are synthesized in good to excellent yield using PEG-400 as a reaction medium. The synthesized compounds are characterized by using different spectroscopic methods like FT-IR, 1H NMR, 13CMR, and HRMS. In this study, the synthesis and biological evaluation of a series of coumarin-appended thiazole hybrids were explored to assess their antibacterial and antifungal properties. Antibacterial activity of the synthesized coumarin-thiazole hybrids was screened against E. coli, P. aeruginosa, S. aureus, and S. pyogenes strains, while antifungal activity was screened against C. albicans, A. niger, and A. clavatus strains. Some of the synthesized compounds showed good antibacterial activity against E. coli and P. aeruginosa strains compared to standard drugs. The ADME profile of these compounds showed favorable pharmacological properties.