Abstract
In a one pot procedure, amines 1a-c, cyclic ketones 3a-f and mercapto acids 2a-c were converted into 1-thia-4-azaspiro(4.n)alkan-3-ones (n = 4-7) 4a-e, 8a-e, 9a and 1-thia-4,8-diaza- spiro(4.5)decan-3-one 9b. The 4-thiazolidinone moiety of 4b and the piperidine ring of 9b were subsequently derivatized furnishing products 5-7 and 10, 12a-d, respectively. The products were evaluated as potential antimycobacterial agents, ten compounds were found active at 25 µg/mL concentration; with the most active compound 12a showing more than 90% inhibition.
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