Synthesis and biological evaluation of 4-dimethylaminobenzaldehyde derivatives of Schiff bases metal complexes: A review

Abstract

• The bio-potent Schiff bases construct distinctively stable transition-metal chelates. • Metal complexes of Schiff bases have offered great deal of pharmacological applications against pathogens. • Binuclear metallic core exhibits double chelating effect in facilitating the penetration. • Screening of the remarkable antimicrobial potential of Schiff bases complexes. Schiff bases are considered as valuable compounds because of their versatility in the field of medicine and pharmaceuticals. A new Schiff base was formed by condensation of 4-dimethylaminobenzaldehyde with benzamide in 1:1 M ratio. The catalytic activity of Schiff base is raised by making its complex with metals. Different transition metals (Ni, Co, Zn, Pb) were used to form the metal complex with the newly formed Schiff base. Metal complexes of Schiff bases derived from 4-dimethylaminobenzaldehyde was processed for good yield of product. The Schiff bases show strong biological activities that includes antifungal, anticancer, antibacterial activities etc. The complexes of Schiff base metal are in the wide range of study. They have high thermal power and have useful effects in many fields. This effect of metal has increased the biological activities of such compounds and therefore the scientists have changed their behavior towards coordination chemistry. The new complexes were also characterized by using UV, IR, XRD and molar conductive techniques. This article throws light on the formation of 4-dimethylaminobenzaldehyde derivatives of different Schiff base metal complexes, its importance and use of Schiff bases along with its metal complexes. The investigation of antibacterial activities of ligand and complexes were done against bacteria like Staphylococcus Aureus , Bacillus subtilis and Escherichia Coli . It was found that the complexes showed marvelous result as compare to ligand against bacteria.