Synthesis and Biological Activity of few Pyrimidines Derivatives against Hepatic Injury Stimulated by Carbon Tetrachloride in Male Rats

Abstract

In the presence of sodium hydroxide, substituted chalcones are reacted with cyanoguandine in ethanol, and some chalcone compounds are used as a nucleus in the preparation of some five-, hexa-, and hepta-, heterocyclic compounds pyrimidine (pyrimidines derivatives), pyrimidine derivatives (A1, A2, and A3). Contains therapeutic properties and bioactivity, and has been used to treat various ailments. This study aimed to learn more about how pyrimidine derivatives could help mitigate the undesirable implications of carbon tetrachloride. a group of 50 male rats were separated into 5 groups: healthy control (no treated), CCl4 group, and the rest. A1 (N-(6-(5-methylthiophen-2yl)-4-phenyl-3,4-dihydropyrimidin- (1H)-ylidene) cyanamide), A2 (N-(6-(5-methylthiophen-2yl)-4-(4-nitrophenyl)-3,4-dihydropyrimidin -2(1H)-ylidene)cyanamide), A3 (N-(4-( Melting points, (FTIR) spectroscopy, 1HNMR spectroscopy, and thin layer chromatography method (TLC) were used to describe compounds [A1, A2 and A3] to monitor the impacted liver function. Pyrimidines derivatives compounds reduced CCl4 toxicity while increasing the levels of aspartate transaminase, alanine transaminase, gamma-glutamyltransferase, and alkaline phosphatase, unlike the CCl4 group and the CCl4 groups containing pyrimidines derivatives. The quantities of total lipids, protein, globulin, and albumin in the control group were substantially different (P0.05). Lipid peroxidation produced a considerable quantity of malondialdehyde compared to the control group, the CCl4 group. However, pyrimidines derivatives components reduced the quantity CCl4, lowering oxidative stress. The levels of catalase, glutathione, and glutathione peroxidase were higher in individuals who were given just CCl4 elevated in groups of pyrimidines derivatives component. There were substantial disparities in superoxide dismutase levels throughout the groups studied.