Synthesis and Assessment of Substituent Effect on (<i>E</i>)-1-(4-Fluoro-3-Methylphenyl)-3-Phenylprop-2-en-1-One Compounds

Abstract

In the present investigation, a series of substituted (E)-1-(4-fluoro-3-methylphenyl)-3-phenylprop-2-en-1-one compounds were synthesized by condensation reaction of 4-fluoro-3-methyl acetophenone with substituted benzaldehydes in the presence of alkali. The yields of synthesized compounds are more than 80%. The structures of all the synthesized compounds were confirmed by their physical constants, UV, IR and NMR spectral data. All the observed spectral data of substituted (E)-1-(4-fluoro-3-methylphenyl)-3-phenylprop-2-en-1-one compounds have been correlated with Hammett substituent constants and F and R parameters using single and multi-linear regression analyses. From the results of statistical analysis the effects of substituents have been discussed.