Synthesis, Hammett Spectral Correlations and Antimicrobial Activities of (<i>E</i>)-1-Benzylidene-2-(4-Chlorophenyl)Hydrazines

Abstract

In the present study, a series of nine number of (E)-1-benzylidene-2-(4-chlorophenyl) hydrazine compounds have been synthesized by condensation reaction of meta and para substituted benzaldehydes with 4-chlorophenylhydrazine using acetic acid catalyst. They are characterized by their physical constants, UV (200-450 nm), Infra-Red (KBr, 4000-400 cm−1) and NMR (1H and 13C) spectral data. The observed UV, IR and NMR spectral data have been correlated with Hammett substituent constants and Swain-Lupton’s F and R parameters using single and multi-linear regression analysis. From the results of statistical analysis the effects of substituents on the spectral data have been discussed. The antimicrobial activities of all the synthesized (E)-1-benzylidene-2-(4-chlorophenyl) hydrazine compounds have been studied using Bauer–Kirby method.