Abstract
We have identified a selective S N2′ reaction triggered by iodide ion that leads to the ring-opening of 2,2′-anhydro-α-nucleosides. By applying the method, we have synthesized α- d-2′,3′-didehydro-2′,3′-dideoxy-3′- C-hydroxymethyl nucleosides, designed as potential antiviral agents.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have