Abstract
New phthalimido derivatives incorporated with chalcone, pyrazole, pyrazoline, and pyrimidine moieties were synthesized and evaluated for their antimicrobial activities against bacterial and fungal strains. 2-{4-[1-Acetyl-5-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenyl} isoindoline-1,3-dione (7) showed broad spectrum antibacterial activity against both G+ and G- bacteria. While, (E)-2-{4-[3-(4-chlorophenyl)acryloyl]phenyl}isoindoline-1,3-dione (4b) showed promising antifungal activity.
Highlights
Despite of increasing synthesis of antimicrobial agents, a big problem is still present
Phthalimides are bicyclic non-aromatic nitrogen heterocycles. They are considered as starting materials and intermediates for the synthesis of different alkaloids [1] .Phthalimides have been received a great deal of attention due to their biological activities such as antibacterial [2,3,4] 1, antifungal [3], anti-inflammatory [5,6,7], antitumor [8,9,10,11], anti HIV-1 [12,13] and anxiolytic activities [14], Figure 1
Chalcones are considered as useful synthons in the synthesis of many bioactive molecules such as: pyrazolines and pyrimidines. Both pyrazolines [2] 1, pyrazoles [22] 2 and pyrimidines [2] 1 have been proved to posses antibacterial [22,23], antifungal [22,23] and antimicrobial [24, 25] activities, Figure 1
Summary
Despite of increasing synthesis of antimicrobial agents, a big problem is still present. They are considered as starting materials and intermediates for the synthesis of different alkaloids [1] .Phthalimides have been received a great deal of attention due to their biological activities such as antibacterial [2,3,4] 1, antifungal [3], anti-inflammatory [5,6,7], antitumor [8,9,10,11], anti HIV-1 [12,13] and anxiolytic activities [14], Figure 1. Chalcones are considered as useful synthons in the synthesis of many bioactive molecules such as: pyrazolines and pyrimidines Both pyrazolines [2] 1, pyrazoles [22] 2 and pyrimidines [2] 1 have been proved to posses antibacterial [22,23] , antifungal [22,23] and antimicrobial [24, 25] activities, Figure 1.
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