Synthesis and antimicrobial activity of new 1,2,3,4-tetrahydropyrimidine-5-carbonyl glycinate silver nanoparticle derivatives

Abstract

A series of silver nanoparticle (AgNPs) with 1,2,3,4 tetrahydropyrimidine derivatives were synthesized and elucidate their structures using physical and spectroscopic techniques (UV.VIS, FTIR, NMR, X-ray diffraction, and SEM). Each of these novel compounds produced spectroscopic data that matched the suggested structures. Pathogenic bacteria and C.albicans were used as test subjects for the antimicrobial activity by using agar well diffusion assay. The AgNPs agents show intermediate activity antimicrobial activities as compare with ciprofloxacin as positive control.