Abstract
An efficient and green methodology to synthesize cyclic dithiocarbamates (compounds 1-11) was developed by reaction of primary amines, CS2 and 1,2-dibromoethane or 1,4-dibromobutane, catalyzed by Triton-B (as PTC)/CS2 system. Mass spectroscopy, elemental analysis and 1H NMR are used for characterization of the synthesized compounds (1-11). This effectual green tactics give good yield of product which entails mild conditions. Compounds (1-11) were found to possess in vitro antimicrobial activities against the pathogenic bacterial and fungal strain. The microbial strains used to screen activities are Escherichia coli, Staphylococcus aureus and Candida albicans.
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